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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2

Fig. 1

Biosynthesis and metabolic pathways of 12(S)-hydroxyheptadecatrienoic acid (12-HHT). Thromboxane (Tx) A2 synthase (TxAS) catalyzes the fragmentation of PGH2 into 12-HHT and malondialdehyde (MDA). TxA2 is unstable in aqueous solution and rapidly hydrolyzed to TxB2, but a proportion of TxA2 is hydrolyzed to 12-HHT and MDA. 12-HHT is metabolized to 12-keto-heptadecatrienoic acid (12-KHT) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH)

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