Fig. 1From: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2Biosynthesis and metabolic pathways of 12(S)-hydroxyheptadecatrienoic acid (12-HHT). Thromboxane (Tx) A2 synthase (TxAS) catalyzes the fragmentation of PGH2 into 12-HHT and malondialdehyde (MDA). TxA2 is unstable in aqueous solution and rapidly hydrolyzed to TxB2, but a proportion of TxA2 is hydrolyzed to 12-HHT and MDA. 12-HHT is metabolized to 12-keto-heptadecatrienoic acid (12-KHT) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH)Back to article page