Fig. 2From: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2Roles of the 12-HHT-LTB4 receptor 2 (BLT2) axis in skin wound healing. BLT2 expressed on the surface of keratinocytes is activated by 12-HHT produced by activated platelets. The 12-HHT-BLT2 axis accelerates keratinocyte migration via the production of tumor necrosis factor (TNF)α, interleukin (IL)-1β, and matrix metalloproteinases (MMPs)Back to article page