Table 1 Physiological and pathophysiological roles of the 12-HHT-BLT2 axis
From: Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B4 receptor 2
| Tissues/cells | In vivo roles of 12-HHT/BLT2 | Possible mechanisms |
|---|---|---|
| Skin | Acceleration of wound healing | Keratinocyte migration |
| Cornea | Acceleration of wound healing | Corneal epithelial cell migration |
| Lung | Protective roles in acute lung injury | Inhibition of CysLT1 signaling |
| Lung | Suppression of asthma | Reduction of IL-13 |
| Cancer | Chemotherapy resistance | Survival of cancer cells |