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Table 1 The classification of PLA2 family. sPLA2, cPLA2, and iPLA2/PNPLA are the original big three among the PLA2 family. The sPLA2 family contains 10 catalytically active isoforms (IB, IIA, IIC, IID, IIE, IIF, III, V, X, XIIA) and 1 inactive isoform (XIIB) in mammals. The cPLA2 family comprises 6 isoforms (α-ζ). The human genome encodes 9 iPLA2 enzymes. These enzymes are now more generally referred to as PNPLA (1–9). In this review, the biological roles of particular PLA2s in the context of skin homeostasis and diseases were described

From: Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

Family Isoforms Gene name Common name Alias Enzyme property
sPLA2 11 PLA2G1B sPLA2-IB Pancreatic sPLA2 PLA2
PLA2G2A sPLA2-IIA Non-pancreatic sPLA2 PLA2
PLA2G2C sPLA2-IIC PLA2
PLA2G2D sPLA2-IID PLA2
PLA2G2E sPLA2-IIE PLA2
PLA2G2F sPLA2-IIF PLA2
PLA2G3 sPLA2-III PLA2
PLA2G5 sPLA2-V PLA2
PLA2G10 sPLA2-X PLA2
PLA2G12A sPLA2-XIIA PLA2
PLA2G12B sPLA2-XIIB Inactive
cPLA2 6 PLA2G4A cPLA2α   PLA2
PLA2G4B cPLA2β PLA1/A2
PLA2G4C cPLA2γ PLA2, transacylase, lysopholipase
PLA2G4D cPLA2δ PLA1/A2
PLA2G4E cPLA2ε PLA1/A2, N-acyltransferase
PLA2G4F cPLA2ζ PLA1/A2
iPLA2/PNPLA 9 PNPLA1   Transacylase
PNPLA2 iPLA2ζ ATGL TG lipase
PNPLA3 iPLA2ε ADPN TG lipase, acyltransferase, restiny-esteryl lipase
PNPLA4 iPLA2η GS2 Retinyl-esteryl lipase?
PNPLA5   GS2L TG lipase
PNPLA6 iPLA2δ NTE Lysophospholipase
PNPLA7   NRE Lysophospholipase
PNPLA8 iPLA2γ   PLA1/A2
PNPLA6 iPLA2β PNPLA9 PLA2