Table 1 The classification of PLA2 family. sPLA2, cPLA2, and iPLA2/PNPLA are the original big three among the PLA2 family. The sPLA2 family contains 10 catalytically active isoforms (IB, IIA, IIC, IID, IIE, IIF, III, V, X, XIIA) and 1 inactive isoform (XIIB) in mammals. The cPLA2 family comprises 6 isoforms (α-ζ). The human genome encodes 9 iPLA2 enzymes. These enzymes are now more generally referred to as PNPLA (1–9). In this review, the biological roles of particular PLA2s in the context of skin homeostasis and diseases were described
From: Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics
Family | Isoforms | Gene name | Common name | Alias | Enzyme property |
|---|---|---|---|---|---|
sPLA2 | 11 | PLA2G1B | sPLA2-IB | Pancreatic sPLA2 | PLA2 |
PLA2G2A | sPLA2-IIA | Non-pancreatic sPLA2 | PLA2 | ||
PLA2G2C | sPLA2-IIC | PLA2 | |||
PLA2G2D | sPLA2-IID | PLA2 | |||
PLA2G2E | sPLA2-IIE | PLA2 | |||
PLA2G2F | sPLA2-IIF | PLA2 | |||
PLA2G3 | sPLA2-III | PLA2 | |||
PLA2G5 | sPLA2-V | PLA2 | |||
PLA2G10 | sPLA2-X | PLA2 | |||
PLA2G12A | sPLA2-XIIA | PLA2 | |||
PLA2G12B | sPLA2-XIIB | Inactive | |||
cPLA2 | 6 | PLA2G4A | cPLA2α |  | PLA2 |
PLA2G4B | cPLA2β | PLA1/A2 | |||
PLA2G4C | cPLA2γ | PLA2, transacylase, lysopholipase | |||
PLA2G4D | cPLA2δ | PLA1/A2 | |||
PLA2G4E | cPLA2ε | PLA1/A2, N-acyltransferase | |||
PLA2G4F | cPLA2ζ | PLA1/A2 | |||
iPLA2/PNPLA | 9 | PNPLA1 | Â | Transacylase | |
PNPLA2 | iPLA2ζ | ATGL | TG lipase | ||
PNPLA3 | iPLA2ε | ADPN | TG lipase, acyltransferase, restiny-esteryl lipase | ||
PNPLA4 | iPLA2η | GS2 | Retinyl-esteryl lipase? | ||
PNPLA5 | Â | GS2L | TG lipase | ||
PNPLA6 | iPLA2δ | NTE | Lysophospholipase | ||
PNPLA7 | Â | NRE | Lysophospholipase | ||
PNPLA8 | iPLA2γ |  | PLA1/A2 | ||
PNPLA6 | iPLA2β | PNPLA9 | PLA2 |