Type of cells | Mechanical stress patterns | Functional changes | Reference |
---|---|---|---|
Human peripheral blood monocytes | Cyclic stretch 7, 12% | Increase in IL-6, MCP-1, IL-10 mRNA | [68] |
Human alveolar macrophages, human monocyte-derived macrophages, human macrophage-like cell line (THP-1) | Cyclic stretch | Increase in IL-8, IL-6, TNF-α protein | [26] |
Human macrophage-like cell line (THP-1) | Cyclic stretch + titanium particles | Increase in COX2 mRNA and PGE2 | [27] |
Rat peritoneal macrophages | Static or cyclic stretch | Static stretch induced iNOS and IL-6 mRNA | [28] |
Rat alveolar macrophages | Cyclic stretch, 60 cycles/min, 30% | No effect on IL-6 and TNF-α protein | [29] |
Mouse macrophage-like cell line (RAW264.7), mouse bone marrow-derived macrophages | Cyclic stretch, 1 Hz | No effect on IL-1β, IL-6, TNF-α, and COX2 mRNA | [30] |
Rat alveolar macrophages | Cyclic stretch, 0.5 Hz, 8–20% | Increase in IL-1β protein | [49] |
Mouse macrophage-like cell line (J774.1), mouse bone marrow-derived macrophages | Cyclic stretch, 1–30 cycles/min, 5–20% | Decrease in IL-1β protein | [51] |
Human macrophage-like cell line (U937) | Cyclic stretch, 0.25 Hz, 10% | Increase in IL-6 protein, esterase, and acidic phosphatase activity | [69] |
Human monocyte-derived macrophages | Cyclic stretch (biaxial), 1 Hz, 4% | Increase in MMP-1, MMP3 mRNA | [31] |
Human monocyte-derived macrophages and osteoclasts | Cyclic stretch + RANKL | Promotes RANKL-induced osteoclastogenesis | [32] |
Mouse macrophage-like cell line (RAW264.7) | Cyclic stretch + RANKL | Inhibits osteoclastogenesis | [33] |
Mouse macrophage-like cell line (RAW264.7) | Short-term cyclic stretch + RANKL | Inhibits osteoclastogenesis | [34] |
Mouse macrophage-like cell line (RAW264.7) | Cyclic stretch, 1 Hz, 1000 μstrain | Inhibits osteoclastogenesis | [35] |
Mouse macrophage-like cell line (RAW264.7) | Compressive force | Promotes osteoclastogenesis | [36] |
Mouse bone marrow macrophages | Compressive force | Promotes osteoclastogenesis | [37] |
Mouse macrophage-like cell line (RAW264.7) | Release of compressive force | Inhibits osteoclastogenesis | [38] |