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Table 1 The effects of mechanical stress on macrophages

From: Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Type of cells Mechanical stress patterns Functional changes Reference
Human peripheral blood monocytes Cyclic stretch 7, 12% Increase in IL-6, MCP-1, IL-10 mRNA [68]
Human alveolar macrophages, human monocyte-derived macrophages, human macrophage-like cell line (THP-1) Cyclic stretch Increase in IL-8, IL-6, TNF-α protein [26]
Human macrophage-like cell line (THP-1) Cyclic stretch + titanium particles Increase in COX2 mRNA and PGE2 [27]
Rat peritoneal macrophages Static or cyclic stretch Static stretch induced iNOS and IL-6 mRNA [28]
Rat alveolar macrophages Cyclic stretch, 60 cycles/min, 30% No effect on IL-6 and TNF-α protein [29]
Mouse macrophage-like cell line (RAW264.7), mouse bone marrow-derived macrophages Cyclic stretch, 1 Hz No effect on IL-1β, IL-6, TNF-α, and COX2 mRNA [30]
Rat alveolar macrophages Cyclic stretch, 0.5 Hz, 8–20% Increase in IL-1β protein [49]
Mouse macrophage-like cell line (J774.1), mouse bone marrow-derived macrophages Cyclic stretch, 1–30 cycles/min, 5–20% Decrease in IL-1β protein [51]
Human macrophage-like cell line (U937) Cyclic stretch, 0.25 Hz, 10% Increase in IL-6 protein, esterase, and acidic phosphatase activity [69]
Human monocyte-derived macrophages Cyclic stretch (biaxial), 1 Hz, 4% Increase in MMP-1, MMP3 mRNA [31]
Human monocyte-derived macrophages and osteoclasts Cyclic stretch + RANKL Promotes RANKL-induced osteoclastogenesis [32]
Mouse macrophage-like cell line (RAW264.7) Cyclic stretch + RANKL Inhibits osteoclastogenesis [33]
Mouse macrophage-like cell line (RAW264.7) Short-term cyclic stretch + RANKL Inhibits osteoclastogenesis [34]
Mouse macrophage-like cell line (RAW264.7) Cyclic stretch, 1 Hz, 1000 μstrain Inhibits osteoclastogenesis [35]
Mouse macrophage-like cell line (RAW264.7) Compressive force Promotes osteoclastogenesis [36]
Mouse bone marrow macrophages Compressive force Promotes osteoclastogenesis [37]
Mouse macrophage-like cell line (RAW264.7) Release of compressive force Inhibits osteoclastogenesis [38]