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Table 4 The total expression ratio of the gene of TGFβ1 in the MEFs treated with various concentrations of methanol extract of Calendula (5 and 10 μg/ml) relative to control group is presented in each time (12 and 24 h after treatment). The statistic test for significance is randomization re-allocation test, implemented in the relative expression software tool. Significant down or upregulations of the genes highlighted

From: Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts via expression of growth factors TGFβ1 and bFGF

  12 h after treatment 24 h after treatment
5 μg/ml 10 μg/ml 5 μg/ml 10 μg/ml
Relative expression 1.3 2.1 0.7 0.62
Standard error ± 0.23 ± 0.24 ± 0.2 ± 0.13
P value 0.265 0.001 0.661 0.001
Fold increase/decrease + 1.3 + 2.1 − 1.06 − 2.5