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Table 2 Effective anti-IL-1 therapy for inflammatory diseases

From: The role of interleukin-1 in general pathology

Autoinflammatory diseases:
 Cryopyrin-associated periodic syndrome (CAPS) [87, 88]
 Familial Mediterranean fever (FMF) [95]
 Pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA) [96]
 NLRP12 autoinflammatory syndrome [97]
 Tumor necrosis factor receptor-1-associated syndrome (TRAPS) [100]
 Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS)/mevalonate kinase deficiency (MKD) [180]
 Deficiency of the interleukin-1-receptor antagonist (DIRA) [183]
Autoimmune diseases:
 Psoriatic arthritis [191]
 Ankylosing spondylitis [192]
 Rheumatoid arthritis (RA) [196]
Metabolic syndrome:
 Gout [203]
 Atherosclerosis [204]
 Type 2 diabetes mellitus (T2D) [204]
 Amyloidosis [207]
Neurodegenerative disease:
 Alzheimer’s disease (AD) [111]
Infections and inflammatory responses:
 Septic shock syndrome [199]
 Acute respiratory distress syndrome (ARDS) [199]
 Disseminated intravascular coagulation (DIC) [199]
 Hemophagocytic lymphohistiocytosis (HLH) [200]
 Macrophage-activating syndrome (MAS) [200]
Ischemic diseases:
 Myocardial infarction (MI) [209]
 Stroke [209]
Malignant rumor:
Breast cancer [129]