Table 2 Effective anti-IL-1 therapy for inflammatory diseases

Autoinflammatory diseases:

 Cryopyrin-associated periodic syndrome (CAPS) [87, 88]

 Familial Mediterranean fever (FMF) [95]

 Pyogenic arthritis, pyoderma gangrenosum and acne syndrome (PAPA) [96]

 NLRP12 autoinflammatory syndrome [97]

 Tumor necrosis factor receptor-1-associated syndrome (TRAPS) [100]

 Hyperimmunoglobulinemia D and periodic fever syndrome (HIDS)/mevalonate kinase deficiency (MKD) [180]

 Deficiency of the interleukin-1-receptor antagonist (DIRA) [183]

Autoimmune diseases:

 Psoriatic arthritis [191]

 Ankylosing spondylitis [192]

 Rheumatoid arthritis (RA) [196]

Metabolic syndrome:

 Gout [203]

 Atherosclerosis [204]

 Type 2 diabetes mellitus (T2D) [204]

 Amyloidosis [207]

Neurodegenerative disease:

 Alzheimer’s disease (AD) [111]

Infections and inflammatory responses:

 Septic shock syndrome [199]

 Acute respiratory distress syndrome (ARDS) [199]

 Disseminated intravascular coagulation (DIC) [199]

 Hemophagocytic lymphohistiocytosis (HLH) [200]

 Macrophage-activating syndrome (MAS) [200]

Ischemic diseases:

 Myocardial infarction (MI) [209]

 Stroke [209]

Malignant rumor:

Breast cancer [129]