Fig. 1
From: Generation of functional human hepatocytes in vitro: current status and future prospects
Approaches to generate hepatocyte progenitors in vitro. Current approaches to generate in vitro-expandable hepatocytes include differentiation of human pluripotent stem cells, reprogramming of fibroblasts and cells of a similar developmental origin, identification of liver progenitor cells, and reprogramming of mature hepatocytes. In vitro-expandable hepatocytes are required as a therapeutic alternative to liver transplantation and for drug development