Table 1 Biochemical composition of hyaline articular cartilage [6, 7]
From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review
Water | Collagens | Proteoglycans | Other molecules | |
|---|---|---|---|---|
% | 70–80(per ww) | 50–75(per dw) | 15–30(per dw) | |
Property | Interstitial fluid | Collagen type II | Aggrecan, (hyaluronan + chondroitin and keratan sulfates | Fibronectin, cartilage oligomeric protein, thrombospondin, tenascin, matrix-GLA (glycine-leucine-alanine) protein, chondrocalcin, and superficial zone protein |
Function | Transporting both nutrients and waste within the tissue | Fibrillar and globular collagen types, such as types V, VI, IX, and XI Intermolecular interactions as well as modulating | Comprised of a protein core with attached polysaccharide chains (glycosaminoglycans). |