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Table 5 Effect of experimental contact shear on chondrocyte proliferation and matrix composition

From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review

 

Hz

% strain

Cell proliferation

Collagen

GAG

Proteoglycan

Scaffold

[15]

1

2

Chondrocyte

40% increase

Not measured

25% increase

(Cpp) calcium poly phosphate

[16]

0.01

0.4–1.6

Chondrocyte

40% increase

Not measured

25% increase

Cartilage disk

[17]

0.1

0.5–6

Chondrocyte

30–35% increase

Not measured

20–25% increase

Cartilage explant

[18]

0.0.1

1–3

Chondrocyte

50% increase

Not measured

25% increase

Cartilage explant

[19]

0.05–0.5

Chondrocyte

Not measured

Not measured

Not measured

Bovine nasal cartilage

[20]

1

Chondrocyte

Not measured

Not measured

Not measured

Agarose

[21]

1

2.5%

Chondrocyte

Increase

Increase

Increase

Agarose gels

[22]

0.1

3

Chondrocyte

30–100% increase

Increase

100–200% increase

Cartilage explant disks

[23]

0.5

Chondrocyte

Not measured

Not measured

Not measured

No scaffolds

[24]

0.05

Chondrocyte

Increase

Increase

Not measured

No scaffolds

[25]

0.5

10–20%

Chondrocyte

Increase

Increase

Increase

Fibrin-polyurethane