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Table 6 Experimental fluid shear by different bioreactor and scaffolds and effects on chondrocyte proliferation and matrix composition

From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review

  RPM Scaffold Cell proliferation Collagen GAG Proteoglycan Type for bioreactor
[26] 80 PGA Chondrocyte Increase 80% Increase Not measured Spinner flask
[27] 50 PGA Chondrocyte Increase Increase Increase Spinner flask
[28] 50 No scaffolds Chondrocyte Increase 125% Increase 60% Not measured Spinner flask
[29] 90 osteochondral tissue Chondrocyte Increase Increase Increase Spinner bioreactor
[30] 50–140 No scaffolds No cell Not measured Not measured Not measured Wavy-walled bioreactor
[31] chitosan/gelatin Adipose-derived stem cells Increase Increase Increase Spinner flask
[32] No scaffolds Chondrocyte Not measured Not measured Not measured 3D finite element model
[33] No scaffolds No cell Not measured Not measured Not measured Hollow fiber (mathematical modeling)
[24] No scaffolds Chondroprogenitor cells Increase Increase Increase Model
[34] No scaffolds No cell Not measured Not measured Not measured Hollow fiber (mathematical modeling)