Table 6 Experimental fluid shear by different bioreactor and scaffolds and effects on chondrocyte proliferation and matrix composition
From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review
RPM | Scaffold | Cell proliferation | Collagen | GAG | Proteoglycan | Type for bioreactor | |
|---|---|---|---|---|---|---|---|
[26] | 80 | PGA | Chondrocyte | Increase 80% | Increase | Not measured | Spinner flask |
[27] | 50 | PGA | Chondrocyte | Increase | Increase | Increase | Spinner flask |
[28] | 50 | No scaffolds | Chondrocyte | Increase 125% | Increase 60% | Not measured | Spinner flask |
[29] | 90 | osteochondral tissue | Chondrocyte | Increase | Increase | Increase | Spinner bioreactor |
[30] | 50–140 | No scaffolds | No cell | Not measured | Not measured | Not measured | Wavy-walled bioreactor |
[31] | – | chitosan/gelatin | Adipose-derived stem cells | Increase | Increase | Increase | Spinner flask |
[32] | – | No scaffolds | Chondrocyte | Not measured | Not measured | Not measured | 3D finite element model |
[33] | – | No scaffolds | No cell | Not measured | Not measured | Not measured | Hollow fiber (mathematical modeling) |
[24] | – | No scaffolds | Chondroprogenitor cells | Increase | Increase | Increase | Model |
[34] | – | No scaffolds | No cell | Not measured | Not measured | Not measured | Hollow fiber (mathematical modeling) |