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Table 7 Effect of perfusion bioreactor on chondrocyte proliferation and matrix composition

From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review

  Pa Rate Cell proliferation Collagen GAG Proteoglycan Scaffold
[35] 0.33 ml/min Chondrocyte Collagen2 increase 240% 300% (S)180% (NS) Increase 35% aggrecan Collagen sponges
[36] 1 μm/s Chondrocyte 155% increase Increase 184% Increase 118% PLLA/PGA
[37] 0.01 Chondrocyte Increase Increase Increase Micro-porous scaffolds
[38] 0.01 0.5 ml/min Chondrocyte Increase Increase Increase Polyestherurethane foams
[39] 0.1. 2 ml/min Chondrocyte Increase Increase Increase Explant
[40] 0.1 ml/min Human mesenchymal stem cells Increase Increase Increase Polycaprolactone (PCL) beads
[41] 3 ml/min Chondrocyte Increase Increase Increase Alginate
[42] 0.33 ml/min Chondrocyte Increase Increase Electrospun poly(ε-caprolactone
[43] 1000, 300 μm/s Chondrocyte Increase Increase Increase Collagen sponges
[44] 0.05–0.45 0.005–0.045 ml/min Chondrocyte Increase Increase Increase Polyurethane
[45] 10 μm/s Chondrocyte Increase Increase Increase No scaffolds