Table 7 Effect of perfusion bioreactor on chondrocyte proliferation and matrix composition
From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review
Pa | Rate | Cell proliferation | Collagen | GAG | Proteoglycan | Scaffold | |
|---|---|---|---|---|---|---|---|
[35] | – | 0.33 ml/min | Chondrocyte | Collagen2 increase 240% | 300% (S)180% (NS) | Increase 35% aggrecan | Collagen sponges |
[36] | – | 1 μm/s | Chondrocyte | 155% increase | Increase 184% | Increase 118% | PLLA/PGA |
[37] | 0.01 | – | Chondrocyte | Increase | Increase | Increase | Micro-porous scaffolds |
[38] | 0.01 | 0.5 ml/min | Chondrocyte | Increase | Increase | Increase | Polyestherurethane foams |
[39] | 0.1. | 2 ml/min | Chondrocyte | Increase | Increase | Increase | Explant |
[40] | – | 0.1 ml/min | Human mesenchymal stem cells | Increase | Increase | Increase | Polycaprolactone (PCL) beads |
[41] | – | 3 ml/min | Chondrocyte | Increase | Increase | Increase | Alginate |
[42] | – | 0.33 ml/min | Chondrocyte | – | Increase | Increase | Electrospun poly(ε-caprolactone |
[43] | – | 1000, 300 μm/s | Chondrocyte | Increase | Increase | Increase | Collagen sponges |
[44] | 0.05–0.45 | 0.005–0.045 ml/min | Chondrocyte | Increase | Increase | Increase | Polyurethane |
[45] | – | 10 μm/s | Chondrocyte | Increase | Increase | Increase | No scaffolds |