Table 8 Effect of perfusion bioreactor with low shear on chondrocyte proliferation and matrix composition
From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review
Pa | RPM | Rate | Cell proliferation | Collagen | GAG | Proteoglycan | Scaffold | Bioreactor | |
|---|---|---|---|---|---|---|---|---|---|
1.10 | – | 0.5–2 | Chondrocyte | Increase | Increase | Increase | Alginate | Perfusion | |
[50] | – | 15–30 | – | Chondrocyte | Increase | Increase | Increase | Hyaluronan benzyl ester non-woven | Rotating |
[51] | – | – | – | No cell | Increase 33% | Increase 68% | Not measured | No scaffolds | Rotating |
[52] | – | – | – | Chondrocyte | Increase 39% | increase 95% | – | No scaffolds | - |
[53] | 17 kPa | 1.32 ml h−1 | Chondrocyte | Increase | Increase | Increase | Scaffold-free | acoustofluidic perfusion |