Skip to main content

Table 8 Effect of perfusion bioreactor with low shear on chondrocyte proliferation and matrix composition

From: Shear bioreactors stimulating chondrocyte regeneration, a systematic review

  Pa RPM Rate Cell proliferation Collagen GAG Proteoglycan Scaffold Bioreactor
[46,47,48,49] 1.10 0.5–2 Chondrocyte Increase Increase Increase Alginate Perfusion
[50] 15–30 Chondrocyte Increase Increase Increase Hyaluronan benzyl ester non-woven Rotating
[51] No cell Increase 33% Increase 68% Not measured No scaffolds Rotating
[52] Chondrocyte Increase 39% increase 95% No scaffolds -
[53] 17 kPa 1.32 ml h−1   Chondrocyte Increase Increase Increase Scaffold-free acoustofluidic perfusion