From: Clinical application of injectable growth factor for bone regeneration: a systematic review
Product name, company, country, year of approval | Target | Growth factor | Carrier | Appearance | Injection use |
---|---|---|---|---|---|
Regranex®, Ortho-McNeil Pharmaceutical, USA, 1997 | Skin ulcer | PDGF-BB | Hydrogel | Gel | Possible, but its use for coating a skin |
InFUSE®, Medtronic, USA, 2002 | Spinal fusion, fracture, bone graft | BMP-2 | Bovine bone collagen | Sheet | No, use in open surgery |
Putty®, Stryker, USA, 2004 | Spinal fusion, fracture | BMP-7/OP-1 | Bovine bone collagen | Gel | Yes |
GEM-21S®, LYNCH Biologics LLC, USA, 2005 | Periodontitis | PDGF-BB | β-TCP | Hard granules | No |
Regroth®, Kaken pharmaceuticals, Japan, 2016 | Periodontitis | FGF-2 | Hydroxypropylcellulose | Gel | Yes, injectable kit for local administration |