Fig. 1
From: Critical roles of super-enhancers in the pathogenesis of autoimmune diseases
Schematic diagram of super-enhancer. SE is a cluster of enhancer that determines cell identity. Transcription factors (TFs) specific to cell types provide a platform for p300, which is recruited to SE domain, extensively mark H3K27me3. Protein complex includes cohesin, CTCF, Med1, and BRD4, and forms loop between SE and promoter, and then induces a powerful transcription of target gene. SE super-enhancer, eRNA enhancer RNA, CTCF CCCTC-binding factor, TF transcriptional factor, Med1 mediator of RNA polymerase II transcription subunit 1, BRD4 bromodomain-containing protein 4, RNAP II RNA polymerase II