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Table 1 Disease-susceptible SNPs in super-enhancers

From: Critical roles of super-enhancers in the pathogenesis of autoimmune diseases

Autoimmune diseases

Affected cell types

Disease-sensitive SNPs (n)

SNPs within SE (n)

Ref.

Rheumatoid arthritis

CD4+ T

101

27

[40, 41]

Systemic lupus erythematosus

N.D.

over 60

N.D.

[42, 43]

Multiple sclerosis

CD4+ T

87

36

[41, 44]

Systemic sclerosis

N.D.

27

N.D.

[45]

Graves’ disease

N.D.

101

N.D.

[46]

Behcet’s disease

N.D.

19

N.D.

[47]

Atopic dermatitis

N.D.

31

N.D.

[48]

Vitiligo

N.D.

over 30

N.D.

[49]

Inflammatory bowel disease

CD4+ T

216

91

[41, 50]

  1. SNPs single nucleotide polymorphisms, SE super-enhancer, N.D. not determined