From: Critical roles of super-enhancers in the pathogenesis of autoimmune diseases
Autoimmune diseases | Affected cell types | SE/eRNA related to diseases | Genes regulated by SE/eRNA | Function | Ref. |
---|---|---|---|---|---|
Rheumatoid arthritis | CD4+T cells | BACH2 SE | IFN-g | Immune response | [41] |
Juvenile idiopathic arthritis | CD4+ memory | CTLA4 SE | CTLA4 | Preserve self-tolerance | [52] |
Effector T cells | CXCR4 SE | CXCR4 | Cell infiltration | [52] | |
Systemic lupus erythematosus | Monocytes | Enhancer 1/2 | ADAMDEC1 | Maintenance of inflammation? | [53] |
PBMCs | PDCD1 SE | PDCD1 | Preserve self-tolerance | [54] | |
Multiple sclerosis | THP-1 cells | VDR SE | USP2 | Proinflammatory cytokine production | [55] |
DENND6B | Cytokine production during inflammation | [55] | |||
Inflammatory bowel disease | CD14+ cells | IFNG-R-49 | N.D. | IL22 gene regulation | [56] |
Vitiligo | Monocyte | HLA class II SE | HLA-DR, -DQ | N.D. | [57] |
PBMCs | HLA class II SE | HLA-DR, -DQ | IL-1b and IFN-g production | [57] | |
Autoimmune uveitis | Th1 cells | T-bet SE/eRNA | IFNg etc. | Cell invasion | [58] |