Fig. 1
From: Immune reaction and regulation in transplantation based on pluripotent stem cell technology
Genetic modification of pluripotent stem cells to suppress or evade recipient immune cell attack. a Gene transduction of CTLA4-Ig and PD-L1 to PSCs. b HLA-I gene knockout in combination with HLA-E gene transduction. c HLA-A, B, and class II gene knockout in combination with retained expression of endogenous HLA-C and E. d HLA-I and II gene knockout in combination with CD47 gene transduction