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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy

Fig. 4

Development of tooth regenerative medicine targeting odontogenic epithelial stem cells. a Cebpb is involved in maintaining the stemness of enamel epithelial stem cells and suppressing epithelial-mesenchymal transition (EMT). Odontogenic epithelial stem cells (OESCs) are differentiated from one of the tissue stem cells; enamel epithelial stem cells and odontogenic mesenchymal cells are formed from odontogenic epithelial cells by EMT. It was demonstrated that both odontogenic epithelial cells and odontogenic mesenchymal cells, required to form teeth from enamel epithelial stem cells, were directly induced to form excess teeth. b Occlusal view of erupted multiple supernumerary teeth derived from odontogenic epithelial stem cells. The yellow arrows indicate the erupted multiple supernumerary teeth

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Inflammation and Regeneration

ISSN: 1880-8190

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