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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Current status and future perspectives of HLA-edited induced pluripotent stem cells

Fig. 1

Schematic representation of the mechanisms for allogeneic iPSC-derived cells to evade immunological rejection. Allogeneic iPSC-derived cell are recognized and eliminated by allo-reactive T cells through HLA class I and class II molecules. Deletion of HLA class I and class II are achieved by B2M and CIITA gene deletion, respectively. On the other hand, loss of HLA class I molecules, which function as ligands for NK inhibitory receptors, causes attack by NK cells. To avoid killing by NK cells, expressions of NK inhibitory ligands, such as HLA-C, HLA-E and CD47 have been reported

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