Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment

Table 1 Summary of the role of fibroblast growth factors (FGFs) which influence on regeneration/neogenesis and growth/maintenance of hair follicle (HF).

Subfamily	Role on HF		Detailed function	Animals	Location	Ref.
Subfamily	Regeneration Neogenesis	Growth Maintenance
FGF1s (1, 2)
FGF1	+	+	Relates with HF differentiation, prevents radiation induced apoptosis of HFs	Ovine, mouse	KC	[15, 16]
FGF2	+	+	Proliferates HF cells, induce HFs, lengthens anagen	Ovine, mouse	KC, DP	[15, 17,18,19]
FGF4s (4, 6, 5)
FGF5		-	Induces catagen, inhibits hair growth by blocking DPC activation	Mouse, rat, cetasean, human		[20,21,22,23]
FGF7s (3, 7, 10, 22)
FGF7	-	+	Protects HF from damage, lengthens anagen, blocks hair follicle induction, related HF texture, proliferates HGs, regulates HF structure	Human, mouse	DP, ORS	[6, 19, 24,25,26,27,28]
FGF10		+	Regulates HF structure, required for HF formation/morphogenesis	Mouse	DP	[26, 29, 30]
FGF9s (9, 16, 20)
FGF9	+		Induces HF neogenesis after wounding	Mouse	γδT cells	[5, 31]
FGF20	+		Governs dermal condensation feather placode induction	Mouse, chicken	Hair placode	[32, 33]
FGF8s (8, 17, 18)
FGF18		−	Induces telogen, stem cell quiescence	Mouse	KC	[34,35,36]
FGF19s (19, 21, 23)
FGF11s (11, 12, 13, 14)
FGF13		+	Regulates function of bulge reduced in hypertrichosis	Mouse	Bulge region	[37]

ISSN: 1880-8190