Skip to main content

Table 1 Summary of the role of fibroblast growth factors (FGFs) which influence on regeneration/neogenesis and growth/maintenance of hair follicle (HF).

From: Altered FGF expression profile in human scalp-derived fibroblasts upon WNT activation: implication of their role to provide folliculogenetic microenvironment

Subfamily Role on HF Detailed function Animals Location Ref.
Regeneration
Neogenesis
Growth
Maintenance
 
FGF1s (1, 2)
FGF1 + + Relates with HF differentiation, prevents radiation induced apoptosis of HFs Ovine, mouse KC [15, 16]
FGF2 + + Proliferates HF cells, induce HFs, lengthens anagen Ovine, mouse KC, DP [15, 17,18,19]
FGF4s (4, 6, 5)
FGF5   - Induces catagen, inhibits hair growth by blocking DPC activation Mouse, rat, cetasean, human   [20,21,22,23]
FGF7s (3, 7, 10, 22)
FGF7 - + Protects HF from damage, lengthens anagen, blocks hair follicle induction, related HF texture, proliferates HGs, regulates HF structure Human, mouse DP, ORS [6, 19, 24,25,26,27,28]
FGF10   + Regulates HF structure, required for HF formation/morphogenesis Mouse DP [26, 29, 30]
FGF9s (9, 16, 20)
FGF9 +   Induces HF neogenesis after wounding Mouse γδT cells [5, 31]
FGF20 +   Governs dermal condensation feather placode induction Mouse, chicken Hair placode [32, 33]
FGF8s (8, 17, 18)
FGF18   Induces telogen, stem cell quiescence Mouse KC [34,35,36]
FGF19s (19, 21, 23)
FGF11s (11, 12, 13, 14)
FGF13   + Regulates function of bulge reduced in hypertrichosis Mouse Bulge region [37]