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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: Possible NK cell-mediated immune responses against iPSC-derived cells in allogeneic transplantation settings

Fig. 2

The mechanism of NK cell-based immune responses. a Inhibitory receptors and ligands of NK cells. HLA-C molecules function as the major ligands of inhibitory receptors expressed on NK cells. HLA-C molecules can be classified into two types, C1 or C2. The receptor for C1 or C2 is KIR2DL3 (2DL3) or KIR2DL1 (2DL1), respectively. b NK cells in recipients carrying HLA-C1/C2 are inhibited by the ligand of either HLA-C1 or HLA-C2 expressed on somatic cells. c It is predicted that HLA-hetero C1/C2 recipient NK cells may sense the missing of the C2 molecule on the graft based on the lack of inhibitory signaling when regenerated tissues derived from HLA-homo iPSCs carrying HLA-C1/C1 are transplanted

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