- This genome-edited HLA-homo-iPSCs was produced using no. 3 shown in Table 1. Because HLA-A, B, and HLA-II was deleted. The frequency of a KIR-ligand mismatch regarding C1/C2 is 7.3% with the same logic used in Table 1 when the genome-edited HLA-homo-iPSCs carrying C1 epitope was used for the allogenic transplantation. In addition, the frequency of KIR-ligand mismatch regarding Bw4 is increased to 50% calculated as [1 − (1 − 0.3) × (1 − 0.3) = 0.51]. The total frequency of at least one mismatch is estimated to be about 54% calculated as [1 − (1 − 0.073) × (1 − 0.5) = 0.537]
