Skip to main content
Fig. 4 | Inflammation and Regeneration

Fig. 4

From: VEGFR1-tyrosine kinase signaling in pulmonary fibrosis

Fig. 4

VEGFR1-TK signaling induces pulmonary fibrosis by VEGFR1+ cells accumulation through the expression of SDF-1/CXCR7/CXCR4 axis. The expression of SDF-1 (a), CXCR7 (b), and CXCR4 (c) in the lung on days 0, 7, 14, and 21 after BLM treatment. Data are expressed as the mean ± SD (n = 3 mice per group). *p < 0.05 versus WT mice. (c) Representative immunohistochemical staining of VEGFR1 in the lung in WT mice and TKKO mice on day 21 after BLM treatment. Bar = 50 μm (d). The number of VEGFR1+ cells in the lung WT mice and TKKO mice on day 21. Data are expressed as the mean ± SD (n = 16 mice per group). ***p < 0.001 versus WT mice. (e) Scheme of VEGFR1-TK signaling on pulmonary fibrosis formation after BLM treatment [11]

Back to article page