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Fig. 1 | Inflammation and Regeneration

Fig. 1

From: Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disorders

Fig. 1

Three forms of autophagy. Cellular components can be delivered into lysosomes for degradation through three distinct autophagic pathways. A During the process of macroautophagy, substrate proteins and organelles are sequestered by autophagosome. Fusion of a lysosome with the autophagosome to form the autolysosome is crucial process for degradation. B During microautophagy, small components of the cytoplasm are engulfed by direct invagination into lysosomes. C CMA degrades soluble proteins containing KFERQ-like motif, which are specifically recognized by chaperone HSC70 and co-chaperones. Lysosome-associated membrane protein type 2A (LAMP2A) is responsible for substrate binding and internalization to lysosome

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