Fig. 4From: Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disordersRole of CMA in COPD pathogenesis. CMA activity is enhanced through Nrf2-mediated LAMP2A expression in response to cigarette smoke exposure. CMA prevent apoptosis by attenuating unfolded protein response (UPR) in non-COPD lung. Impaired CMA activity resulting from reduced Nrf2 expression leads to enhanced UPR with concomitantly enhanced apoptosis during COPD pathogenesisBack to article page