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Fig. 14 | Inflammation and Regeneration

Fig. 14

From: Molecular biology of autoinflammatory diseases

Fig. 14

Type I interferon signaling in interferonopathies. Type I interferon singling is closely linked to innate immune receptors such as cGAS, MDA5, and RIG-I that are sensing viral, bacterial, or own DNA or RNA. Interferon-stimulated genes (ISGs) are induced by interferon regulatory factors (IRFs) downstream of cGAS, MDA5, and RIG-I. Immunoproteasome dysfunction is also linked to interferonopathies

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