Skip to main content
Fig. 16 | Inflammation and Regeneration

Fig. 16

From: Molecular biology of autoinflammatory diseases

Fig. 16

Mutations in αCOP in patients with COPA syndrome. Mutations in αCOP (e.g., K230N) impair ER-Golgi transport resulting in ER stress-induced NF-κB activation and the mutant αCOP retention of STING on the Golgi resulting in STING activation leads to prolonged type I interferon signaling

Back to article page