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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Molecular biology of autoinflammatory diseases

Fig. 3

Prolonged activation of pyrin inflammasome in patients with familial Mediterranean fever (FMF). Upon Yersinia pestis-like bacterial infection, Yersinia outer protein (Yop)M interacts with pyrin to inhibit pyrin inflammasome to avoid further anti-bacterial responses. In patients with FMF, pyrin-harboring mutant human B30.2 domains enable to interact with YopM, resulting in prolonged pyrin inflammasome activation and IL-1β secretion

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