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Fig. 5 | Inflammation and Regeneration

Fig. 5

From: Molecular biology of autoinflammatory diseases

Fig. 5

Activation of pyrin inflammasome in patients with pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Pyrin mutations in patients with PAAND (e.g., S242R and E244K) mutations are located in the 14-3-3 binding motif, which interferes with the binding of pyrin to 14-3-3, thereby allowing activation of the pyrin inflammasome

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Inflammation and Regeneration

ISSN: 1880-8190

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