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Table 1 The corresponding diseases caused by the similar signaling of autoinflammatory diseases

From: Molecular biology of autoinflammatory diseases

Type of autoinflammatory diseases Responding proteins Functions Corresponding diseases with the similar signaling
Inflammasomopathies
CAPS Cryopyrin/NLRP3 PRR for ROS, K+ efflux, cathepsin B detection Metabolic syndrome:
Gout [42]
Atherosclerosis [43]
Type 2 diabetes [44]
Neurodegenerative disease:
Alzheimer’s disease [45, 46]
Parkinson’s disease [47]
Amyotrophic lateral sclerosis [48]
Multiple sclerosis [49]
Infections and aberrant inflammatory responses:
Septic shock syndrome [50, 51]
Ischemic diseases:
Myocardial infarction [52]
Stroke [53]
NAIAD NLRP1 PRR against Anthrax toxin detection Infections and aberrant inflammatory responses:
Anthrax lethal toxin [54]
Neurodegenerative disease:
Alzheimer’s disease [46]
Ischemic diseases:
Stroke [53]
NLRP12-AD NLRP12 PRR for Yersinia pestis detection Infections and aberrant inflammatory responses:
Yersinia pestis [55]
Plasmodium chabaudi [56]
NF-κB inhibition Regulation of inflammation:
Salmonella typhimurium [57]
Brucella abortus [58]
TRAPS TNFRSF1A TNF receptor Infections and aberrant inflammatory responses:
Tumor necrosis factor [59]
APLAID PLCγ2 Cleavage PIP to DAG Immunodeficiency:
Common variable immunodeficiency [60]
PLCγ2-associated antibody deficiency and immune dysregulation syndrome (PLAID) [60]
Familial cold autoinflammatory syndrome 3 [60]
Neurodegenerative disease:
Alzheimer’s disease [61, 62]
Lewy body dementia [62]
Frontotemporal dementia [62]
FMF Pyrin Virulence sensor Infections and aberrant inflammatory responses:
Yersinia pestis infection [63]
PFIT WDR1 Actin assembly, leukocyte migration Infections and aberrant inflammatory responses:
Listeria monocytogenes dissemination [64]
PAAND Pyrin Virulence sensor Infections and aberrant inflammatory responses:
Yersinia pestis infection [63]
PAPA syndrome PSTPIP1/CD2BP1 Pyrin regulation Immunodeficiency:
Common variable immunodeficiency [65]
MKD MVK Lipid metabolism Metabolic syndrome:
Atherosclerosis [66]
NLRC4 inflammasomopathies NLRC4 PRR for flagellin detection Infections and aberrant inflammatory responses:
Pseudomonas aeruginosa infection [67]
Macrophage activation syndrome (MAS) [68]
Relopathies
BS/EOS NOD2 PRR for MDP Infections and aberrant inflammatory responses:
Mycobacterium tuberculosis infection [69]
HA20 A20/TNFAIP3A Deubiquitinating for NF-κB regulation Infections and aberrant inflammatory responses:
Systemic lupus erythematosus (SLE) [70]
Rheumatoid arthritis [71]
IAALUCD LUBAC Ubiquitinating for NF-κB regulation Infections and aberrant inflammatory responses:
HOIL-1/ RBCK1 Salmonella enterica infection [72]
HOIP/RNF31 Legionella pneumophila infection [72]
SHARPIN Shigella flexneri infection [72]
ORAS OTULIN Deubiquitinating for NF-κB regulation Infections and aberrant inflammatory responses:
Salmonella Typhimurium infection [73]
IL-1 receptor-related autoinflammatory diseases:
DIRA IL1RN IL-1 receptor inhibitor Infections and aberrant inflammatory responses:
Inflammasomopathies [74]
Interferonopathies
AGS RNASEH2 RNase activity against viral RNA Infections and aberrant inflammatory responses:
SLE and other autoimmune diseases [75, 76]
Cervical cancer via human papilloma virus [77]
SAMHD1 dNTPase activity against viral RNA/DNA Epstein-Barr virus infection [78]
Human immunodeficiency virus infection [79]
ADAR1 Viral RNA processing Hepatitis B virus infection [80]
Marburg and Ebola virus [81]
MDA5/IFIH1 PRR for viral RNA detection Paramyxovirus infection [82]
Picornavirus infection [83]
SAVI STING/TMEM173 PRR for viral DNA/RNA detection Infections and aberrant inflammatory responses:
SLE and other autoimmune diseases [76]
ANCA-associated vasculitis [84]
Herpes simplex virus infection [85]
COPA syndrome αCOP Transport vesicles between Golgi to ER Infections and aberrant inflammatory responses:
Interstitial lung disease [86]
Capillaritis [87]
PRAAS/NNS/CANDLE PSMB3,4,8,9 Proteasome for antigen processing Infections and aberrant inflammatory responses:
SLE and other autoimmune disease [87, 88]
Cytomegalovirus infection [89]
Hepatitis B virus infection [90]
Influenza virus infection [91]
POMP Proteasome chaperone Infections and aberrant inflammatory responses:
Psoriasis [92]
Human papilloma virus infection [93]
SMS MDA5/IFIH1 PRR for viral RNA detection Infections and aberrant inflammatory responses:
SLE and other autoimmune diseases [75, 76, 94]
Paramyxovirus infection [82]
Picornavirus infection [83]
RIG-I PRR for viral RNA detection Infections and aberrant inflammatory responses:
SLE and other autoimmune diseases [95]
Paramyxovirus infection [83]