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Table 1 LEC subsets in human and mouse LNs

From: A short review on lymphatic endothelial cell heterogeneity

Subset names

Localization

Uniquely expressed genes

Proposed functions

Human (Takeda et al.)

Mouse

#1 Xiang et al.

#2 Fujimoto et al.

LEC I

cLEC

cLEC

Subcapsular sinus (ceiling)

CCRL1, NT5E, CAV1 (human), Ackr4, Foxc2 (mouse #1)

Ackr4, CD36, Ackr3, Bgn (mouse #2)

Chemokine scavenging?

LEC II

fLEC

fLEC

Subcapsular sinus (floor)

TNFRSF9, MARCO, CCL20 (human)

Madcam1, Ccl20, Cd274 (mouse #1)

Cd44, Glycam1, Coch (mouse #2)

Chemokine

Presentation/scavenging?

LEC III

  

Capsule ceiling overlying the medulla

CCRL1, LYVE1, MFAP4 (human)

 

LEC IV

  

Head and neck LNs

CAV1, LYVE1 (human)

 

LEC V

Valve

 

Lymphatic valve

CAV1, NT5E, CLDN11 (human)

Ackr4, Foxc2, Ccl21a (mouse #1)

 

LEC VI

Marco-LEC

Medullary LEC

Medulla

CLEC4G, CLEC4M, CD209 (human)

Cd274, Lyve1, Marco (mouse #1)

Marco, Itga2b, Lyve1 (mouse #2)

Neutrophil trapping?

 

Ptx3-LEC

Egress sinus LEC

Cortical/medullary sinuses

Lyve1, CCL21a,Ptx3 (mouse #1)

Ptx3, Kcnj8, Itih5 (mouse #2)

Lymphocyte egress?

  1. CCRL1 the human gene encoding the chemokine receptor CCRL1 (chemokine-C-C-motif receptor-like protein-1) or ACKR4 (atypical chemokine receptor 4), which binds dendritic cell- and T cell-activated chemokines including CCL19, CCL21, and CCL25
  2. NT5E the human gene encoding the purine catabolic enzyme ecto 5′-nucleotidase (CD73), which is a plasma membrane protein that catalyzes the conversion of extracellular AMP (adenosine monophosphate) to adenosine
  3. CAV1 the human gene encoding a scaffolding protein, caveolin-1, which is the main component of caveola plasma membranes
  4. Ackr4 the mouse gene encoding the chemokine receptor ACKR4 (atypical chemokine receptor 4) or CC chemokine receptor type 11 (CCRL1)
  5. Foxc2 the mouse gene encoding a member of the Forkhead box (FOX) family of transcription factors, Foxc2. Mutation of this gene is observed in patients with lymphedema–distichiasis syndrome, which is characterized by late childhood- or pubertal-onset lymphedema of the limbs. Lymphatic valves and mural cell recruitment are thought to be defective in these patients
  6. CD36 the mouse gene encoding the scavenger receptor class B, member 3, which binds and internalizes oxidized low-density lipoprotein
  7. Ackr3 the mouse gene encoding the chemokine receptor AKCR3 (atypical chemokine receptor 3) or CXC chemokine receptor 7 (CXCR7), which can bind the chemokines CXCL12 and CXCL11
  8. Bgn the mouse gene encoding biglycan, which is a small leucine-rich repeat proteoglycan (SLRP) found in the extracellular matrix of various tissues
  9. TNFRSF9 the human gene encoding TNF receptor superfamily member 9 (TNFRSF9), which is also called 4-1BB or CD137
  10. MARCO the human gene encoding macrophage receptor with a collagenous structure (MARCO), which is a class A scavenger receptor that can bind modified low-density lipoproteins such as oxidized low-density lipoproteins
  11. CCL20 the human gene encoding CC motif chemokine ligand 20 (CCL20), which is strongly chemotactic for cells expressing the chemokine receptor CCR6
  12. Madcam1 the mouse gene encoding mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is an endothelial molecule that interacts with leukocyte alpha4beta7 (α4β7) integrin
  13. Cd274 the mouse gene encoding CD274 or programmed cell death 1 ligand 1 (PD-L1), which binds the receptor PD1 abundantly expressed on activated T cells and blocks T cell activation
  14. Cd44 the mouse gene encoding CD44, which is a cell-surface glycoprotein that plays a role in cell adhesion and migration
  15. Glycam1 the mouse gene encoding glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1), a cell-surface protein that binds the leukocyte receptor L-selectin
  16. Coch the mouse gene encoding cochlin, which is an extracellular matrix protein that binds collagen VII. Cochlin-deficient mice show a higher frequency of infection with Pseudomonas aeruginosa and Staphylococcus aureus
  17. LYVE1 the human gene encoding lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), which is a cell-surface glycoprotein that binds hyaluronic acid
  18. MFAP4 the human gene encoding microfibril-associated glycoprotein 4 (MFAP4), which is an extracellular matrix protein involved in intercellular interactions
  19. CLDN11 the human gene encoding claudin 11, which is a tight junction protein involved in the minimization of intercellular space
  20. Ccl21a the mouse gene encoding CC motif chemokine 21 (CCL21), which induces chemotaxis of naïve T cells and dendritic cells by binding to the chemokine receptor CCR7
  21. CLEC4G the human gene encoding C-type lectin domain family 4 member G (CLEC4G), which is a cell-surface C-type lectin receptor involved in innate immune responses
  22. CLEC4M the human gene encoding C-type lectin domain family 4 member M (CLEC4M), which binds intercellular adhesion molecule-3 (ICAM-3) as well as the gp120 molecule of HIV-1
  23. CD209 the human gene encoding dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) or CD209, which binds to various pathogen-associated molecular patterns (PAMPs) found on viruses, bacteria, and fungi
  24. Itga2b the mouse gene encoding integrin alpha chain 2b, which joins with integrin beta 3 chain to form a heterodimeric protein, α2β3 integrin
  25. Ptx3 the mouse gene encoding pentraxin-related protein 3 (PTX3), which is involved in the regulation of innate resistance to pathogens
  26. Kcnj8 the mouse gene encoding potassium inwardly rectifying channel, subfamily J, member 8 (KCNJ8)
  27. Itih5 the mouse gene encoding inter-alpha-trypsin inhibitor heavy chain 5 (ITIH5)
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Inflammation and Regeneration

ISSN: 1880-8190

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