Fig. 1
From: Endothelial-specific depletion of TGF-β signaling affects lymphatic function
TβRIIiΔLEC mice exhibit embryonic edema and abnormal lymphatic vessel structure. a Treatment protocol for i.p. administration of tamoxifen (Tx). Pregnant mice were injected with Tx at E10.5 and E11.5, and embryos were analyzed at E13.5. b Gross analysis of TβRIIfl/fl; Prox1-CreERT2 (TβRIIiΔLEC), and littermate control (TβRIIfl/fl) embryos at E13.5. Mild edema (arrowhead) and blood clots (arrows) are observed in TβRIIiΔLEC pups. Scale bar: 1 mm. c. Back skin immunohistochemistry of mice embryos at E13.5 with anti-LYVE-1 (green) and anti-PECAM-1 (red) antibodies. Scale bar: 100 μm