Table 1 List of EndoMT-related markers and inflammation-related genes in articles introduced in this review
From: Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
Inducer/trigger | Inflammation signal | EC gene | Mesenchymal gene | Transcription factor | |
|---|---|---|---|---|---|
BMP9 | CCL2 | APLN | ACTA2/SMA | MMP14 | HES1 |
MMP14/MT1-MMP (macrophage) | CCL3 | CDH5/VE-cadherin | CDH2 | MMP2 | HEY1 |
TGFB1 | CXCL2 | ERG | CNN1/SM-calponin | MMP9 | HEY2 |
TGFB2 (endothelial) | ICAM1 | FGFR1 | COL12A1 | NOTCH3 | MKL1/MRTFA |
| Â | IFNG | FLT4 (lymphatic EC) | COL1A1 | PCOLCE | SNAI1 |
| Â | IL1B | FSTL3 | COL1A2 | PDGFRB | SNAI2 |
| Â | IL4 | KDR | COL2A1 | Â | TWIST1 |
| Â | IL6 | lncRNAH19 | COL3A1 | S100A4/FSP1 | TWIST2 |
| Â | JAK | LYVE1 (lymphatic EC) | COL6A1 | SERPINE1/PAI1 | ZEB1 |
| Â | RELA | MIR126 | CTGF | TAGLN | ZEB2 |
| Â | STAT3 | MIRLET7/let-7 | FAP | TGFBI | Â |
| Â | TNFA | NOS3/eNOS | FN1 | TNC | Â |
| Â | VCAM1 | PDPN (lymphatic EC) | LAMC2 | VIM | Â |
| Â | Â | PECAM1/CD31 | LY6A/Sca1 | Â | Â |
| Â | (EndICLT marker) | PROX1 (lymphatic EC) | Â | Â | |
| Â | C1QA | PTGDS/L-PGDS | Â | Â | |
| Â | C1QB | SCL (EC/hematopoietic) | ATG5low (endothelial) | Â | |
| Â | C5AR1 | TIE1 | ATG16Llow (endothelial) | Â | |
| Â | Â | TIE2 (EC/hemopoietic) | TRP53low (endothelial) | Â | |
| Â | Â | VWF | Â | Â | |
| Â | Â | WNT5A | Â | Â | |