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Fig. 10 | Inflammation and Regeneration

Fig. 10

From: Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1

Fig. 10

Analysis of apoptosis in mPGES-1−/− colons. A Representative images of Swiss-roll colon sections on day 7 after the start of exposure to 1% DSS. Arrows indicate apoptotic cells. Scale bar, 50 μm. B Quantification of apoptotic cells in colon (n = 5). C mRNA expressions of an anti-apoptotic factor Bcl2 and apoptotic markers, Bak, Bid, Bim, Bad, and Noxa, in colon from mice treated with 1% DSS for 7 days were analyzed by real-time RT-PCR (n = 7 to 10). Levels of mRNA expression are shown as the fold induction relative to the expression in WT mice without DSS administration (assigned the value “1”). *P < 0.05; 2-way ANOVA followed by Tukey multiple comparison test

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