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Fig. 7 | Inflammation and Regeneration

Fig. 7

From: Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1

Fig. 7

Generation of IL-17A- and IFNγ-producing T cells in colonic LPMCs and splenocytes of mPGES-1−/− mice with DSS-induced colitis. A Representative FCM plot of IL-17A-producing Th17 cells and IFNγ-producing Th1 cells in CD3+CD4+ T cells of splenocytes and colonic LPMCs isolated from WT and mPGES-1−/− mice with colitis. Colonic LPMCs were pooled from 4 mice in each experiment on day 7 after the start of exposure to 1% DSS and analyzed by FCM, as described in the Methods (n = 5). B The ratio and the number of IL-17A+ and IFNγ+ cells in CD3+CD4+ T cells of colonic LPMCs on day 7 after the start of exposure to 1% DSS (n = 5). *P < 0.05 vs WT; t test

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