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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Axon guidance molecules in immunometabolic diseases

Fig. 3

Role of semaphorin signaling in the pathogenesis of atherosclerosis. Sema4D promotes the development of atherosclerosis by promoting thrombus formation, intimal neovascularization, and recruitment of macrophages into atherosclerotic plaques. In addition, Sema7A aggravates plaque formation in atherosclerosis by promoting leukocyte adhesion and vascular inflammation. In contrast, Sema3A inhibits leukocyte rolling, adhesion, and transmigration into atherosclerotic lesions, resulting in the suppression of inflammatory responses in atherosclerosis

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