Fig. 4

Co-stimulatory blockade alleviates immune response against human iPSC-derived liver organoids. (A) Schematic overview of human iPSC-derived liver organoid transplantation. (B) Human albumin concentration in the serum of liver organoid recipient mice (n = 12, control; n = 8-9, non-treatment; n = 7, CB; n = 5, CB + rapa). *p < 0.05, **p < 0.01 (two-way repeated measure ANOVA Tukey’s multiple comparisons test). hiPSC, human iPSC; tx, transplantation; CB, co-stimulatory molecule blocking; rapa, rapamycin; POD, post-operative day; hALB, human albumin