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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Morphological heterogeneity description enabled early and parallel non-invasive prediction of T-cell proliferation inhibitory potency and growth rate for facilitating donor selection of human mesenchymal stem cells

Fig. 3

Morphological profile analysis of 11 lots of MSCs. a Early time-course transitions of “area” distribution comparing 11 lots. Low-risk lots: Lots 1–7, High-risk lots: Lots 8–11, categorized by the T-cell proliferation inhibitory potencies. b Comparison of SDs of “area” among Low-risk lots and High-risk lots at 12, 36, 78 h at their early time-course. Asterisks indicate p < 0.05 by Student’s t-test. c PCA mapping of 11 lots by morphological profiles. Each lot is depicted with the same color dots (3 wells). Dotted circle indicates the cluster of High-risk lots. d Hierarchical clustering of 11 lots by morphological profiles. Columns consist of 3 wells × 11 lots, and rows indicate morphological profiles (32 parameters × 22 time points). The heat map under the clustering tree shows their measured potencies (T-cell proliferation score, and growth rate)

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Inflammation and Regeneration

ISSN: 1880-8190

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