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Fig. 4 | Inflammation and Regeneration

Fig. 4

From: A case of refractory systemic lupus erythematosus with monocytosis exhibiting somatic KRAS mutation

Fig. 4

Sanger sequence results of Kras. A The chromatograms are showing wild type Kras DNA in the PBMC of healthy control (HC), and in another patient with systemic lupus erythematosus (SLE), whereas mutated Kras (c.G35A) DNA was detected from PBMC of the patient (P). The same mutation is not detected in mucosa of the patient of interest (P-mucosa). B The chromatograms are showing the same mutation site of Kras from sorted T cells, monocytes and cerebrospinal fluid (CSF). C Kras genomic sequence of the patient was wild type when she was diagnosed with SLE. However, Kras mutation (c.G35A) manifested spontaneously at the time when she developed encephalomyelitis, and persisted for 5 years after the encephalomyelitis diagnosis (ED)

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