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Fig. 2 | Inflammation and Regeneration

Fig. 2

From: The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

Fig. 2

The intrinsic pathway of SASP induction in senescence: activation of cGAS-STING pathway by abnormal cytoplasmic DNA fragments. Abnormal cytoplasmic DNA fragments produced during cellular senescence act as a ligand of the DNA sensor, cGAS-STING. The cGAS, cyclic GMP-AMP synthase, triggers the reaction to produce cyclic di-nucleotide, cyclic GMP-AMP (cGAMP), that is recognized by STING, thereby facilitating the type 1 interferon-producing pathway activated by phosphorylated IRF3. Normally, DNases such as DNase2 and TREX1 degrade cytoplasmic DNA fragments emanating from the nucleus or damaged mitochondria. In senescent cells, the expression of these DNases is downregulated, resulting in cytoplasmic accumulation of DNA fragments. The remaining DNA fragments aberrantly activate the cytoplasmic DNA sensor, cGAS-STING

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Inflammation and Regeneration

ISSN: 1880-8190

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