Skip to main content
Fig. 3 | Inflammation and Regeneration

Fig. 3

From: The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

Fig. 3

The role of SASP in tumor microenvironment. The effects of the SASP depends on the tumor stage. In precancerous cells (or in a very early stage of cancer), which are known to be in the senescent state, the effects of the SASP factors from the precancerous cells are predominantly tumor-suppressive, recruiting immune cells to exclude precancerous senescent cells (senescence surveillance). However, in advanced stage of tumor tissues, the SASP factors from senescent cancer-associated fibroblasts (CAFs) support the proliferation of cancer cells and promote tumor progression

Back to article page