Fig. 7
TA improves cognitive function and ameliorates the Aβ pathology and neuronal damage in APP/PS1 mice. A The cognitive function of NC and APP/PS1 mice was evaluated by the MWM test. Bar charts indicate the escape latencies, the ratio of time spent in the target quadrant/total time, the number of mice crossing the platform, and average swimming speed (n ≥ 4). B The Western blotting detection of the protein expressions of Aβ, caspase-9, Bax, and Bcl-2 in the brain tissues of NC and APP/PS1 mice. Bar charts indicate the ratios of Aβ/β-actin, caspase-9 (p19)/Pro, Bax/Bcl-2. The full-length blots are presented in Additional file 1: Fig. S25. C Representative immunohistochemistry and immunofluorescence staining images showing the expressions of Aβ, NeuN, Bax, and TUNEL-positive neurons in the hippocampus of NC and APP/PS1 mice. Magnification: × 20; scale bar: 100 μm. Bar charts indicate the quantification of Aβ, NeuN, Bax, and TUNEL-positive neurons (n = 4). Error bars, S.D. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001, n = 4. (One-way ANOVA with Tukey-corrected post hoc t-tests for multiple comparisons was applied for comparison between groups)