Skip to main content

Table 1 Extracellular vesicle subcategories

From: Extracellular vesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics

EV subgroup

Size (nm)

Formation

Markers

Exosome (small EV)

30–150

Fusion of multivesicular bodies with the plasma membrane

ESCRT-associated proteins (Tetraspanins, ALIX, and TSG101)

Microvesicle (medium/large EV)

50–1000

Direct budding and cleavage of the plasma membrane

Cytoskeletal and plasma membrane proteins (origin cell-specific markers)

Apoptotic body (large EV)

>1000

Cytoplasmic fragmentation during programmed cell death

Proteins associated with the Golgi, endoplasmic reticulum, nucleus, and other cellular organelles.