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Fig. 3 | Inflammation and Regeneration

Fig. 3

From: Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases

Fig. 3

Potentially therapeutic skin microbiota by pathogen elimination. Engraftment of specific skin microbiota that play a role in killing the pathogen is a therapeutic strategy for skin inflammatory diseases such as atopic dermatitis and acne. Colonization of Staphylococcus aureus is inhibited by bacterial metabolites such as antimicrobial peptides (AMPs), autoinducing peptides, and antibiotics. Bacteriophages kill and lyse the bacteria that they infect. Staphylococcus epidermidis promotes the production of AMPs from host cells through the Toll-like receptor 2 (TLR2) response. Dendritic cells (DCs) capture S. epidermidis and induce IL-17A+ CD8T cells via a nonclassical MHC I-restricted pathway. Induced IL-17A+ CD8T cells produce cytokines that stimulate keratinocytes to produce AMPs against pathogens

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