Fig. 4
From: Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases
Potentially therapeutic host-microbe interactions. Colonization with specific skin commensals provides beneficial responses. Staphylococcus epidermidis stimulates immune cells such as lymphocytes and neutrophils to promote tissue repair. pDCs recruited by CXCL10 from neutrophils produce type-1 IFNs that activate tissue repair response. In parallel, IL-17A+ CD8T cells induced by S. epidermidis colonization show immunoregulatory and tissue repair signature genes. Roseomonas mucosa promotes tissue repair via Toll-like receptor 5 (TLR5) stimulation by tumor necrosis factor (TNF) signaling. The combination of isolated skin microbiota that is dominant in healthy human skin improves adherence and differentiation of keratinocytes through aryl hydrocarbon receptor (AhR) signaling. Staphylococcus cohnii promotes local steroid synthesis that suppresses types 2 and 17 skin inflammation