From: Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases
Reference | Experimental model | Target disease | Applied bacteria | Results |
---|---|---|---|---|
Myles et al. [133] | Human | AD | Roseomonas mucosa | Topical R. mucosa showed therapeutic activity against AD in adults and children without adverse events or treatment complications. (Decreases in disease severity, topical steroid requirement, and S. aureus burden) |
Myles et al. [141] | Murine Human | AD | Roseomonas mucosa | R. mucosa application ameliorated disease severity of AD in children without severe adverse events. (Decreased disease severity, reduced S. aureus burden on the skin, and a reduction in topical steroid requirements, improvement in epithelial barrier function) |
Nakatsuji et al. [78] | Murine Human | AD | Autologous bacterial transplant (Staphylococcus epidermidis, Staphylococcus hominis) | Reintroduction with antimicrobial strains of S. epidermidis or S. hominis decreased colonization density of S. aureus in AD patients |
Williams et al. [139] | Murine | AD | Staphylococcus hominis | S. hominis inhibited S. aureus toxin production by quorum sensing and prevented S. aureus-mediated skin inflammation |
Ito et al. [51] | Murine | AD | Staphylococcus cohnii | Colonization of S. cohnii ameliorated both AD-like dermatitis and psoriasis-like skin inflammation |
Nakatsuji et al. [140] | Murine Human | AD | Staphylococcus hominis | Typical S. hominis A9 showed fewer adverse events and decreased S. aureus colonization in AD patients. (S. hominis A9 did not significantly improve disease severity but inhibited expression of toxin from S. aureus) |
Nakatsuji et al. [142] | Human | AD | Allogeneic bacterial transplant (CoNS strains with antimicrobial activity) | Application of CoNS reduced S. aureus burden on lesional skin of AD patients without serious adverse events. (Decreased S. aureus burden, improved local disease severity score) |
Karoglan et al. [143] | Human | Acne | Cutibacterium acnes from healthy individuals | Applied C. acnes reduced non-inflamed lesions (open and closed comedones) and skin pH without untoward adverse events |
Lebeer et al. [144] | Human | Acne | Lactobacilli strains | Application of Lactobacilli strains reduced inflammatory lesions of acne. (Reduced relative abundance of staphylococci and Cutibacterium acnes) |
Nakatsuji et al. [86] | Murine | Skin tumor | Staphylococcus epidermidis | S. epidermidis strain producing 6-N-hydroxyaminopurine (6-HAP) reduced the incidence of ultraviolet-induced tumors |