Fig. 2From: Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challengesDiagram of the formation of neurofibrillary tangles. Under normal conditions, tau binds to the microtubules facilitating microtubule assembly and promoting microtubule stabilization. In AD, the abnormally phosphorylated tau dissociates from the microtubules, and the phosphorylated tau proteins form neurofibrillary tanglesBack to article page