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Table 2 Human studies of the intestinal virome in autoimmune diseases

From: Characterization of the human gut virome in metabolic and autoimmune diseases

Disease

Study population

References

IA

children with high-risk HLA genotypes who seroconverted (n= 19, 18) and matched controls in Finland

[48, 49]

IA

children with high-risk HLA genotypes who seroconverted (n= 11) and matched controls in Finland and Estonia

[50]

IA/T1DM

children with high-risk HLA genotypes (n= 10: seroconverted, n= 6; progressed to T1DM, n= 4) and non-seroconverted control individuals (n= 8) in Finland and Estonia

[51]

At risk for RA

FDRs of individuals with RA (n= 16: with anti-CCP antibodies, n= 8; without anti-CCP antibodies, n= 8) and healthy matched controls (n= 9) in the United States

[52]

RA, SLE, MS

patients with RA (n= 111), SLE (n= 47), MS (n= 29) and healthy controls (n= 289) in Japan

[53]

  1. Abbreviations: IA Islet autoimmunity, HLA Human leukocyte antigen, T1DM Type 1 diabetes mellitus, FDR First-degree relative, SCCP Cyclic citrullinated peptide, RA Rheumatoid arthritis, SLE Systemic lupus erythematosus, MS Multiple sclerosis
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