Fig. 1

Cytokines and cytokine receptor families involved in immune-mediated diseases. White boxes in the top part of the figure list the cytokines implicated in IMID, which bind the cytokine receptors schematically depicted below. Horizontal gray bar represents the cell membrane. Under the cell membrane, signaling systems located downstream of the cytokine receptors are indicated. Gray boxes on the right list biological agents located outside the cells (top) and JAK inhibitors located inside the cells (bottom)